From Milan and Rome:

Exit from the A1 motorway at Florence-Impruneta. Take the Superstrada towards Siena and exit at San Casciano V.P. Take the Via Cassia (SR2) towards San Casciano and after you have passed the town 2 kms on the left you will see the Relais Poggio Borgoni entrance.

From the Amerigo Vespucci Airport in Florence – 28 kms:
Exit from the airport taking the motorway towards Rome, at the Firenze Nord junction, take the A1 motorway towards Rome, and exit the A1 motorway at Florence-Impruneta. Take the Superstrada towards Siena and exit at San Casciano V.P. Take the Via Cassia (SR2) towards San Casciano and after you have passed the town, 2 kms on the left you will see the Relais Poggio Borgoni entrance.

From the Galileo Galilei Airport in Pisa – 74 kms:

Exit from the airport taking the S.G.C. Fi-Pi-Li motorway for 60 kms and exit at Ginestra
Fiorentina, Turn RIGHT ON SP12 towards Cerbaia and follow the directions to San Casciano. Once in San Casciano follow the directions for Siena on the Via Cassia. After you have passed the town, 2 kms on the left you will see the Relais Poggio Borgoni entrance.

GPS: Nord 43° 38' 33'' - Est 11° 10' 36''